000			01614nam a22002537a 4500
005			20231116100800.0
008			231020b ||||| |||| 00| 0 eng d
022			_a0021-9584
037			_bRIEBPL Library
082			_a540.7
100			_aJinkun Fan et al...
245			_a Application of Electrochemical Chlorination Reaction in Organic Laboratory Course _b (Journal Article)
260			_aUSA _b:American Chemical Society _cAugust 2023
300			_a3008-3016 P.
490			_aAmerican Chemical Society, Volume 100, Issue 8
505			_a***______{For Hard Copy, Please visit Library.}________***
520			_aAbstract The chlorination reaction of aromatic compounds is highly important for the synthesis of pharmaceutical products. As the most common chlorination reagent, chlorine is restricted from undergraduate laboratory experiment training due to its toxicity. In this work, we reported the chlorination of aromatic compounds with chlorine generated from the paired electrolysis of N-chlorosuccinimide. The chlorine in this reaction is produced and consumed in an on-demand manner, ensuring the safety of the reaction, workup, and purification. The reaction is evaluated with 5 undergraduate students with reproducible results and conveys the basic concepts of electrochemical organic synthesis and green synthesis to these students.
650			_aSecond-Year Undergraduate
650			_aOrganic Chemistry
650			_a Hands-On Learning/Manipulatives
650			_aElectrochemistry
856			_u https://doi.org/10.1021/acs.jchemed.2c01088
942			_cPER
999			_c44879 _d44878