000			01794nam a22002657a 4500
005			20231020161118.0
008			231020b ||||| |||| 00| 0 eng d
022			_a0021-9584
037			_bRIEBPL Library
082			_a540.7
100			_aMichaela Kuchynka et al...
245			_a Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: _bAn Experiment for Undergraduate Analytical Chemistry Laboratory (Journal Article)
260			_aUSA _b:American Chemical Society _c,May 2023
300			_a1973–1979p.
490			_aAmerican Chemical Society, Volume 100, Issue 5
505			_a***______{For Hard Copy, Please visit Library.}________***
520			_aAbstract- A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub μg·g–1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student’s task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.
650			_aQuantitative Analysis
650			_aUpper-Division Undergraduate
650			_aAnalytical Chemistry
650			_aLasers
650			_aMass Spectrometry
856			_u https://pubs.acs.org/doi/epdf/10.1021/acs.jchemed.2c01111
942			_cPER
999			_c44572 _d44571