TY  - BOOK
AU  - Crespi, Ayelén F.  
AU  - Lázaro-Martínez, Juan M. 
TI  - Can a gem-Diol Moiety Be Isolated? : A Reaction Study by NMR and X-ray Spectroscopies (Journal Article)
SN  - 0021-9584
PY  - 2023///
CY  - Washington DC 
PB  - :American Chemical Society 
KW  - Organic Chemistry| Heterocyclic Compounds | Undergraduate Students| Carbonyl Moieties gem-Diols| NMR X-ray Crystallography
N1  - ***______{For Hard Copy, Please visit Library.}________***


N2  - Abstract: The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a gem-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of gem-diols is not usually covered in depth in organic chemistry courses. Herein, we propose a two-step activity to study the isolation of different gem-diols: an organic laboratory practice designed for undergraduate students combined with an in-class activity. The approach focuses on the study of heterocyclic compounds with aldehyde moieties using solution and solid-state nuclear magnetic resonance combined with X-ray crystallography
UR  - https://doi.org/10.1021/acs.jchemed.3c00446
ER  -