01631nam a22002057a 4500 20240530121042.0 240530b |||||||| |||| 00| 0 eng d 0021-9584 Crespi, Ayelén F. Can a gem-Diol Moiety Be Isolated? A Reaction Study by NMR and X-ray Spectroscopies (Journal Article) Washington DC :American Chemical Society ,2023 4536–4542p. Journal of Chemical Education Volume 100, 2023 - Issue 11, November 2023 ***______{For Hard Copy, Please visit Library.}________*** Abstract: The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a gem-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of gem-diols is not usually covered in depth in organic chemistry courses. Herein, we propose a two-step activity to study the isolation of different gem-diols: an organic laboratory practice designed for undergraduate students combined with an in-class activity. The approach focuses on the study of heterocyclic compounds with aldehyde moieties using solution and solid-state nuclear magnetic resonance combined with X-ray crystallography. Organic Chemistry| Heterocyclic Compounds | Undergraduate Students| Carbonyl Moieties gem-Diols| NMR X-ray Crystallography Lázaro-Martínez, Juan M. https://doi.org/10.1021/acs.jchemed.3c00446 PER 0 0 0 0 RIEBPL RIEBPL 2024-05-30 0 2024-05-30 12:10:55 2024-05-30 PER 45975 45974