01942nam a22002057a 4500 20240530111408.0 240530b |||||||| |||| 00| 0 eng d 0021-9584 Sharma, Sudripet Rapid Amide Coupling in Water for Undergraduate Laboratories (Journal Article) Washington DC :American Chemical Society ,2023 4406–4413p. Journal of Chemical Education Volume 100, 2023 - Issue 11, November 2023 ***______{For Hard Copy, Please visit Library.}________*** Abstract: Chemistry in water is an emerging field that fulfills the fifth principle of green chemistry: replacing toxic organic solvents with their benign counterparts. Although some pharmaceutical industries have developed and adopted chemistry in water, its implementation in teaching laboratories is still limited. Therefore, we have designed an experiment dedicated to the undergraduate curriculum covering sustainable, completely organic-solvent-free amide coupling, which is one of the most heavily used reactions in the pharmaceutical industry. The designed experiment aims to acquaint students with the 12 principles of green chemistry, inform them of the shortcomings of the traditional synthetic procedures of amide coupling, make them aware of waste generation from toxic organic solvents, and show them the effectiveness of water as a benign reaction medium. With the training throughout the lab sessions, students were taught micellar catalysis, NMR (nuclear magnetic resonance) spectroscopy, IR (infrared) spectroscopy, separation techniques, and safety data. green chemistry| amide couplings| micellar catalysis| organic-solvent-free chemistry Ansari, Tharique N. | Kaur, Karanjeet | Gorce, Andrea | Braje, Wilfried M. | Handa, Sachin https://doi.org/10.1021/acs.jchemed.3c00350 PER 0 0 0 0 RIEBPL RIEBPL 2024-05-30 0 2024-05-30 11:14:31 2024-05-30 PER 45958 45957