01665nam a22001937a 4500 20240409094026.0 240409b |||||||| |||| 00| 0 eng d 0002-7685 Hoh, Yin Kiong The First Three Decades of Gene Therapy : An Instant Update (Journal Article) United States :National Association of Biology Teachers (NABT) ,2023 17–22p. American Biology Teacher Volume 85: Issue 1, January 2023 ***______{For Hard Copy, Please visit Library.}________*** Abstract: Gene therapy has fascinated clinicians, scientists, and patients since decades ago because of its potential to treat a disease at the genetic level. This can be achieved in many ways, including replacing a disease-causing gene with a healthy copy. Gene therapy must overcome complex tissue and cellular barriers to introduce genetic modifications into the nucleus of the target cells to drive a high level of gene expression. Moreover, the genetically corrected cells must be present in significantly large numbers in the body to reverse the diseased condition and yet able to escape immunological recognition and survive in the long term to sustain the benefit. This paper reviews the early work as well as recent developments in gene therapy, including improvements to viral vectors and novel treatment strategies, diseases targeted, approved gene therapies, and current challenges and prospects for future progress. gene therapy| somatic gene therapy| germline gene therapy https://doi.org/10.1525/abt.2023.85.1.17 PER 0 0 0 0 RIEBPL RIEBPL 2024-04-09 0 2024-04-09 09:40:34 2024-04-09 PER 45651 45650