(Journal Article) Jinkun Fan et al... creator text USA :American Chemical Society August 2023 monographic eng

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3008-3016 P. Abstract The chlorination reaction of aromatic compounds is highly important for the synthesis of pharmaceutical products. As the most common chlorination reagent, chlorine is restricted from undergraduate laboratory experiment training due to its toxicity. In this work, we reported the chlorination of aromatic compounds with chlorine generated from the paired electrolysis of N-chlorosuccinimide. The chlorine in this reaction is produced and consumed in an on-demand manner, ensuring the safety of the reaction, workup, and purification. The reaction is evaluated with 5 undergraduate students with reproducible results and conveys the basic concepts of electrochemical organic synthesis and green synthesis to these students. ***______{For Hard Copy, Please visit Library.}________*** Second-Year Undergraduate Organic Chemistry Hands-On Learning/Manipulatives Electrochemistry 540.7 0021-9584 RIEBPL Library https://doi.org/10.1021/acs.jchemed.2c01088 https://doi.org/10.1021/acs.jchemed.2c01088 231020 20231116100800.0