01614nam a22002537a 4500 20231116100800.0 231020b ||||| |||| 00| 0 eng d 0021-9584 RIEBPL Library 540.7 Jinkun Fan et al... Application of Electrochemical Chlorination Reaction in Organic Laboratory Course (Journal Article) USA :American Chemical Society August 2023 3008-3016 P. American Chemical Society, Volume 100, Issue 8 ***______{For Hard Copy, Please visit Library.}________*** Abstract The chlorination reaction of aromatic compounds is highly important for the synthesis of pharmaceutical products. As the most common chlorination reagent, chlorine is restricted from undergraduate laboratory experiment training due to its toxicity. In this work, we reported the chlorination of aromatic compounds with chlorine generated from the paired electrolysis of N-chlorosuccinimide. The chlorine in this reaction is produced and consumed in an on-demand manner, ensuring the safety of the reaction, workup, and purification. The reaction is evaluated with 5 undergraduate students with reproducible results and conveys the basic concepts of electrochemical organic synthesis and green synthesis to these students. Second-Year Undergraduate Organic Chemistry Hands-On Learning/Manipulatives Electrochemistry https://doi.org/10.1021/acs.jchemed.2c01088 PER 0 0 0 0 RIEBPL RIEBPL 2023-11-16 0 540.7 2023-11-16 00:00:00 2023-11-16 PER 44879 44878