(Journal Article) James A. McKee et al... creator text USA :American Chemical Society August 2023 monographic eng

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2981-2985 P. Abstract Electrophilic aromatic substitution reactions are common in the organic chemistry laboratory. These reactions, while ubiquitous, use corrosive reagents and halogenated or hydrophobic solvents that produce expensive and hazardous waste streams. The carboxylation of phenols (Kolbe–Schmitt reaction), although aqueous, typically involves conditions (high pressure/temperature) that are not well-suited for a large teaching laboratory. The following experiment modifies the Kolbe–Schmitt process for ambient pressures and aqueous reflux temperatures. This procedure is safe, simple, and inexpensive and uses 13C NMR as an analytical tool to confirm product synthesis and investigate changes in molecular symmetry. ***______{For Hard Copy, Please visit Library.}________*** Second-Year Undergraduate Upper-Division Undergraduate Organic Chemistry Laboratory Instruction NMR Spectroscopy Green Chemistry Hands-On Learning/Manipulatives 540.7 0021-9584 RIEBPL Library https://pubs.acs.org/doi/epdf/10.1021/acs.jchemed.2c00165 https://pubs.acs.org/doi/epdf/10.1021/acs.jchemed.2c00165 231020 20231116095809.0