01433nam a22001937a 4500 20231027123444.0 231027b ||||| |||| 00| 0 eng d 0021-9584 Lucy, Charles A. Is Your Henderson–Hasselbalch Calculation of Buffer pH Correct? (Journal Article) Washington DC :American Chemical Society ,2023 2418-2422p. Journal of Chemical Society , Volume 100: Number 6, June 2023 ***______{For Hard Copy, Please visit Library.}________*** Abstract: A survey of 21 free online buffer calculators and apps found only 2 that correctly calculated pH under conditions where [H+] and [OH–] cannot be ignored in the ratio term of the Henderson–Hasselbalch equation. Traditional guidelines for when use of formal concentrations is acceptable were found to be flawed. For acidic (pKa ≤ 7) buffers, the use of formal concentrations is valid when FA–/Ka > 20. For alkaline (pKa ≥ 7) buffers, the approximation is valid when FBH+/Kb > 20. Robust equations for predicting pH of acidic and alkaline buffers are presented, which could be used with programmable calculators and should be used for online buffer calculators and apps. Buffers| Acid−Base Chemistry| Analytical Chemistry| General Chemistry https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01203 PER 0 0 0 0 RIEBPL RIEBPL 2023-10-27 0 2023-10-27 00:00:00 2023-10-27 PER 44628 44627