Pavlov, Julius creator Errabelli, Ramu | Xu, Sihang | Zheng, Zhaoyu | Douce, David | Bajic, Steve | Attygalle, Athula B. text Washington DC :American Chemical Society ,2023 monographic eng

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2207-2214p. Abstract: The helium-plasma (HePI) ionization mass spectrometry method was used to track the formation of reaction products and consumption of reactants by continually monitoring the vapors in the reaction headspace in real time. Two examples of the application procedure are presented here: a nucleophilic acyl substitution reaction and a 1,4-nucleophilic addition process. For the purposes of the work, a specially constructed helium-plasma ionization (HePI) source was mounted on a single-quadrupole benchtop mass spectrometer. However, any electrospray source is easily convertible to an ambient HePI source. This setup has the potential to be used in the teaching of organic and analytical chemistry laboratories, as well as for demonstrations. Because the procedure requires only the headspace of the reaction vessel to be sampled by an easily prepared Venturi suction device (pump), the experiments can be quickly set up and adapted for any available mass spectrometer equipped with an electrospray source. For sampling, students can be shown how to prepare their own Venturi pumps and conduct reactions at different temperatures. ***______{For Hard Copy, Please visit Library.}________*** Ionization | Ions | Mass spectrometry | Piperidines| Organic Chemistry| Helium Plasma Ionization| Online Reaction Monitoring 0021-9584 https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01150 https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01150 231022 20231022154629.0