TY  - BOOK
AU  - Michaela Kuchynka et al...
TI  -  Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: : An Experiment for Undergraduate Analytical Chemistry Laboratory   (Journal Article)
T2  - American Chemical Society, Volume 100, Issue 5
SN  - 0021-9584
U1  - 540.7 
PY  - 2023///
CY  - USA
PB  - :American Chemical Society
KW  - Quantitative Analysis
KW  - Upper-Division Undergraduate
KW  - Analytical Chemistry
KW  - Lasers
KW  - Mass Spectrometry
N1  - ***______{For Hard Copy, Please visit Library.}________***
N2  - Abstract-
 
A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub μg·g–1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student’s task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.



 





UR  -  https://pubs.acs.org/doi/epdf/10.1021/acs.jchemed.2c01111
ER  -