01794nam a22002657a 4500 20231020161118.0 231020b ||||| |||| 00| 0 eng d 0021-9584 RIEBPL Library 540.7 Michaela Kuchynka et al... Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory (Journal Article) USA :American Chemical Society ,May 2023 1973–1979p. American Chemical Society, Volume 100, Issue 5 ***______{For Hard Copy, Please visit Library.}________*** Abstract- A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub μg·g–1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student’s task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount. Quantitative Analysis Upper-Division Undergraduate Analytical Chemistry Lasers Mass Spectrometry https://pubs.acs.org/doi/epdf/10.1021/acs.jchemed.2c01111 PER 0 0 0 0 RIEBPL RIEBPL 2023-10-20 0 540.7 2023-10-20 00:00:00 2023-10-20 PER 44572 44571